Treatment of dyslipidemia in diabetes

Atherosclerosis kills more patients with diabetes than all other causes combined. Treatment must be focused on several targets: glycemic control, bulk reductions of LDL cholesterol, and shifting LDL particle size. Aggressive treatment and reversal of dyslipidemias is a proven prevention for coronary events in patients with type 2 diabetes. Glycemic control with diet, oral hypoglycemic agents, and insulin, when necessary, often is only partially effective in normalizing lipid values in type 2 diabetes. Intensive treatment with lipid-regulating agents, particularly statins, often is necessary to normalize diabetes-associated dyslipidemias. Statins also are the only agents thus far shown in prospective, controlled trials to reduce the risk of coronary events in diabetic patients definitively.