Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 115, Issue 3, Pages 707-709Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2001.03156.x
Keywords
Gaucher disease; vitamin B-12 deficiency; homocysteine; methylmalonic acid; environmental factors
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This study ascertained serum vitamin B-12 levels among patients with Gaucher disease and among healthy Israelis. Serum B-12 and metabolites' levels were studied in consecutive adult patients with Gaucher disease not treated with enzyme plus Ashkenazi Jewish neighbour-controls, together with healthy blood-donor volunteers of various ethnicities. Each group showed a high incidence of low serum B-12 concentrations, with a 22.3% incidence among Ashkenazi Jews and 40% among patients with Gaucher disease. These findings raise questions on the individual and community levels of serum B-12, We recommend evaluation of B-12 levels among geographically contingent peoples.
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