Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 27, Issue 6, Pages 633-638Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2001-18867
Keywords
fibrinolysis; sepsis; plasminogen activator inhibitor type 1; PAI-1; plasminogen activators; multiple organ failure syndrome; MOFS
Categories
Ask authors/readers for more resources
Studies in experimental models for sepsis, the most common cause of disseminated intravascular coagulation (DIC), have put forward the concept of a procoagulant state that is characterized by thrombin generation exceeding that of plasmin. Convincing evidence indicates that this imbalance between coagulation and fibrinolysis is due to increased levels of plasminogen activator inhibitor type 1 (PAI-1). Levels of this fibrinolysis inhibitor indeed correlate with outcome and severity of multiple organ failure in patients with sepsis, as well as in patients with DIC from other causes. Hence we suggest that PAI-1 constitutes an important target for therapy in patients with DIC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available