Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 31, Issue 14, Pages 1601-1607Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0020-7519(01)00295-8
Keywords
Taenia solium; cytochrome oxidase I; internal transcribed spacer I; species/strain identification; sequence variation; cysticercosis
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We examined the genetic variability in the pig-human tapeworm, Taenia solium, by sequencing the genes for cytochrome oxidase 1, internal transcribed spacer 1, and a diagnostic antigen, Ts14, from individual cysts isolated from Peru, Colombia, Mexico, India, China, and the Philippines. For these genes. the rate of nucleotide variation was minimal. Isolates from these countries can be distinguished based on one to eight nucleotide differences in the 396 nucleotide cytochrome oxidase I (COI) sequence. However, all of the 15 isolates from within Peru had identical COI sequences. The Ts14 sequences from India and China were identical and differed from the Peru sequence by three nucleotides in 333. These data indicate that there is minimal genetic variability within the species T. solium. Minimal variability was also seen in the ITSI sequence, but this variation was observed within the individual. Twenty-two cloned sequences from six isolates sorted into 13 unique sequences. The variability observed within the sequences from individual cysts was as great as the variability between the isolates. Published by Elsevier Science Ltd. on behalf of Australian Society for Parasitology.
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