Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 91, Issue 6, Pages 2735-2741Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jappl.2001.91.6.2735
Keywords
steroids; electric fields
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Monodisperse aerosols show therapeutic advantages, but they are difficult to generate. A new method (electrohydrodynamic atomization) is described. A high voltage is applied to a nozzle through which a solution, containing dissolved drug, is pumped. At the nozzle tip, a liquid cone is formed and a stream of monodisperse droplets is released. The droplet diameter is governed by the density, conductivity, and the flow rate of the fluid. The droplets are charged and need to be neutralized. Therefore, a corona discharge system is used. Methylparahydroxybenzoate was used as a model drug, and additional data were generated by using beclomethasone dipropionate (BDP). At a flow rate of 1 ml/h and 0.5% methylparahydroxybenzoate, 1.58-mum particles were produced with a geometric SD of 1. 18. Increasing the flow rate to 3 ml/h and the concentration to 3% resulted in 4.55-mum particles with a geometric SD of 1.29. The experiments with BDP resulted in similar particle sizes. The mass of BDP was found to range between 1.42 and 6 mug/l air. Aqueous solutions cannot be sprayed by using this setup. This method can be used to deliver antiasthma drugs to patients.
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