Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 115, Issue 4, Pages 1004-1006Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2001.03184.x
Keywords
thrombopoietin; thrombocytopenia; immune; purpura; platelet kinetics
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Pre- and post-treatment serum thrombopoietin (TPO) concentration was measured In 35 patients with immune thrombocytopenic purpura (ITP). Mean post-treatment levels were significantly lower (P = 0.02) than pretreatment and not different for treatment modality. No significant correlation between pre- or post-treatment TPO and platelet counts was demonstrable (R = -0.325, P = 0.056 and R = -0.227, P = 0.190 respectively). In patients with very low platelet counts (less than or equal to20 x 10(9)/l), pretreatment serum TPO was significantly higher than in patients with higher counts (P = 0.033). The logarithm of the platelet turnover rate. measured in 15 patients, correlated with pretreatment TPO levels (R = 0.64). These findings suggest a contributory role for TPO in the mechanism of ITP.
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