Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 23, Pages 11930-11934Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.23.11930-11934.2001
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Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIVmac239) DNA or SIVmac239 DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIVmac239 DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIVmac251 challenge.
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