Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 13, Issue 6, Pages 639-643Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(01)00272-2
Keywords
-
Categories
Funding
- NCI NIH HHS [CA57855] Funding Source: Medline
- NIDDK NIH HHS [DK57644, DK50824] Funding Source: Medline
Ask authors/readers for more resources
Autoimmunity can be viewed as the price we pay in order to have a highly diverse TCR repertoire. This is not to say that every effort isn't made by the immune system to prevent autoimmune disease. During thymic development, and later in the periphery, the TCR repertoire is continuously purged of cells that are activated by self-antigens. Other lymphocytes are recruited to join a legion of T regulatory cells that assist in preventing 'friendly fire', Recent studies continue to reveal the importance of the composition of the T cell repertoire in predisposing an individual to autoimmune disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available