Journal
JOURNAL OF IMMUNOLOGY
Volume 167, Issue 11, Pages 6441-6446Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.167.11.6441
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Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated NMC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum. via the TAP.
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