Journal
JOURNAL OF CHEMOTHERAPY
Volume 13, Issue 6, Pages 611-614Publisher
E I F T SRL
DOI: 10.1179/joc.2001.13.6.611
Keywords
Pistacia lentiscus; mastic gum; antibacterial activity; Helicobacter pylori; electron microscopy
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In this study we evaluated the antibacterial activity of mastic gum, a resin obtained from the Pistacia lentiscus tree, against clinical isolates of Helicobacter pylori. The minimal bactericidal concentrations (MBCs) were obtained by a microdilution assay. Mastic gum killed 50% of the strains tested at a concentration of 125 mug/ml and 90% at a concentration of 500 mug/ml. The influence of sub-MBCs of mastic gum on the morphologies of H. pylori was evaluated by transmission electron microscopy. The lentiscus resin induced blebbing, morphological abnormalities and cellular fragmentation in H. pylori cells.
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