Journal
GENOMICS
Volume 78, Issue 3, Pages 135-149Publisher
ACADEMIC PRESS INC
DOI: 10.1006/geno.2001.6647
Keywords
migraine; migraine gene; complex disease; association mapping; linkage disequilibrium mapping; insulin receptor; SNPs; disease susceptibility
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We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.
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