Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 23, Pages 11868-11873Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.23.11868-11873.2001
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A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.
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