Journal
IMMUNITY
Volume 15, Issue 6, Pages 871-882Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(01)00246-1
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Funding
- NIAID NIH HHS [R01 AI46719] Funding Source: Medline
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Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8+ T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L- T cell effector memory (T-EM) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA-CD62L- T-EM cells. However, cytotoxicity and IFN gamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CDW T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.
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