Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 13, Issue 6, Pages 644-649Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(01)00273-4
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There is now compelling evidence that CD4(+) T cells that specialise in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery. These cells have also been identified in humans, paving the way for analysis of the function of CD4(+) regulatory T cells in immune-mediated disease.
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