Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 15, Issue 5, Pages 677-691Publisher
ELSEVIER SCI LTD
DOI: 10.1053/berh.2001.0187
Keywords
rheumatoid arthritis; Th1/Th2; autoimmunity; cytokines; pathogenesis; treatment
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It has been suggested that rheumatoid inflammation is mediated by activated pro-inflammatory T helper type 1 cells. In contrast, immunomodulatory T helper type 2 cells and their cytokines, in particular interleukin-4, are rarely found. This chapter reviews the concept of the Th1/Th2 dichotomy and summarizes the functions of the signature cytokines of the T helper subsets. We discuss current knowledge of the immunopathogenesis of rheumatoid arthritis and its related animal model, collagen induced arthritis, with regard to the Th1/Th2 paradigm. The accumulating evidence for a T helper type 1 driven inflammation and the implications for future therapy are delineated.
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