Journal
BLOOD REVIEWS
Volume 15, Issue 4, Pages 159-166Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1054/blre.2001.0162
Keywords
reactive thrombocytosis; familial thrombocytosis; essential thrombocythemia; myeloproliferative disorders; clonality; megakaryocytopoiesis; thrombopoietin; thrombosis; cytoreduction; antiplatelet therapy
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Thrombocytosis is caused by three major pathophysiological mechanisms: (1) reactive or secondary thrombocytosis; (2) familial thrombocytosis; and (3) clonal thrombocytosis, including essential thrombocythemia and related myeloproliferative disorders. Recent work has begun to elucidate the abnormal megakaryocytopoiesis of essential thrombocythemia, which is associated with paradoxically elevated plasma levels of thrombopoietin. The clonal nature of all cases of essential thrombocythemia has been challenged. Thrombotic complications are the major causes of morbidity and mortality in this disease, Indications for platelet cytoreduction and antiplatelet therapy, as well as complications of treatments are being clarified. (C) 2001 Harcourt Publishers Ltd.
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