Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 12, Issue 6, Pages 632-637Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0958-1669(01)00272-5
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Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
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