Journal
BLOOD
Volume 98, Issue 12, Pages 3261-3273Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V98.12.3261
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL 32262] Funding Source: Medline
- NIDDK NIH HHS [K08 DK002668] Funding Source: Medline
Ask authors/readers for more resources
Erythropoietin (Epo) controls red cell production in the basal state and during stress. Epo binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the transcription factor Stat5. Previously, fetal anemia and increased apoptosis of fetal liver erythroid progenitors were found in Stat5a(-/-)5b(-/-) mice. However, the role of Stat5 in adult erythropoiesis was not clear. The present study shows that some adult Stat5a(-/-)5b(-/-) mice have a near-normal hematocrit but are deficient in generating high erythropoletic rates in response to stress. Further, many adult Stat5a(-/-)5b(-/-) mice have persistent anemia despite a marked compensatory expansion in their erythropoletic tissue. Analysis of erythroblast maturation in Stat5a(-/-)5b(-/-) hematopoletic tissue shows a dramatic increase in early erythroblast numbers, but these fail to progress in differentiation. Decreased expression of bcl-(XL) and increased apoptosis in Stat5a(-/-)5b(-/-) early erythroblasts correlate with the degree of anemia. Hence, Stat5 controls a rate-determining step regulating early erythroblast survival. (Blood. 2001;98:3261-3273) (C) 2001 by The American Society of Hematology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available