Journal
INFECTION GENETICS AND EVOLUTION
Volume 1, Issue 2, Pages 143-150Publisher
ELSEVIER
DOI: 10.1016/S1567-1348(01)00018-1
Keywords
Trypanosoma brucei; Trypanosoma cruzi; Evolution; Phylogenetics; Maximum likelihood; Small subunit ribosomal RNA; Biogeography
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Funding
- Wellcome Trust [050808/Z/97/Z, 50275]
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Ribosomal RNA-based studies of trypanosome phylogenies have highlighted considerable differences in genetic diversity within clades in the genus Trypanosoma and several-fold substitution rate differences between clades have been identified. While early 18S rRNA-based studies were hampered by highly variable substitution rates and long-branch attraction, it is apparent that genuine differences in evolution rates within localized clades do exist and questions remain regarding what rate or rates such clades are evolving at and why is the application of a single clock to trypanosome evolution so inappropriate? In this study, we explore rate heterogeneity in the commonly used 18S rRNA gene across genus Trypanosoma, using a maximum likelihood (ML) approach to explore local rate variations in clades of biological interest. (C) 2001 Elsevier Science B.V. All rights reserved.
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