Journal
CELL BIOCHEMISTRY AND FUNCTION
Volume 19, Issue 4, Pages 265-271Publisher
WILEY
DOI: 10.1002/cbf.924
Keywords
sodium selenite; hepatoma; TCA cycle enzymes; N-nitrosodiethylamine
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The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N-nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and a-ketoglutarate dehydrogenase (alpha -KGDH) in hepatoma and surrounding tissues of hepatoma-bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose- and duration-dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis. Copyright (C) 2001 John Wiley & Sons, Ltd.
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