Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 12, Pages 1576-1578Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np010280b
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Four new alkaloids (1-4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1-4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 mug/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC50 values of 1.1, 0.66, and 2,5 mug/mL, respectively.
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