Journal
NATURE CELL BIOLOGY
Volume 3, Issue 12, Pages 1092-1100Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1201-1092
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Adenovirus type 2 (Ad2) imports its DNA genome through the nuclear pore complex (NPC) of cells in interphase for viral production. Here we identify the NPC-filament protein CAN/Nup214 as a docking site for incoming Ad2 capsids. Binding to CAN is independent of cytosolic factors. Capsids disassemble at NPCs to free their DNA for import. This process requires binding of nuclear histone HI to the stably docked capsids and involves Hl-import factors, restricting this irreversible process to the proximity of the nucleus. Our results provide a molecular mechanism for disassembly of Ad2 and reveal an unexpected function of histone H1 in virus-mediated DNA import.
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