Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 27, Issue 6, Pages 639-651Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2001-18868
Keywords
cytokines; endotoxin; coagulation; fibrinolysis; protein C
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Disseminated intravascular coagulation (DIC) can complicate a number of diseases. DIC in the setting of sepsis is considered to result from strong activation of the coagulation system and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection.
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