New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease

Inflammatory bowel disease (IBD) and multiple sclerosis (MS) are autoimmune diseases with a close relationship to their disease pattern add immunologic cascade with considerable morbidity and mortality. This article provides insight of why tumor necrosis factor blockers couldn't work in multiple sclerosis and why interferon-beta doesn't work in inflammatory bowel disease. In this article, we provide a detailed review of the linkage and potential interchangeable medication between IBD and MS in addition to Natalizumab, Trichuris suis egg therapy and vitamin D. Different treatment strategies may have potential in treating both diseases in the future. Published by Elsevier B.V.