Journal
AUTOIMMUNITY REVIEWS
Volume 12, Issue 12, Pages 1160-1165Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2013.07.003
Keywords
MicroRNA; Sex hormones; Autoimmunity; Systemic lupus erythematosus; Cancer; Rheumatoid arthritis and Sjogren syndrome
Categories
Funding
- NIH [AR54034, AI 083894, AI65645]
- UCLA
- American Autoimmune Related Disease Association
- Arthritis Foundation Pacific Region
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miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options. (C) 2013 Elsevier B.V. All rights reserved.
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