Journal
SEMINARS IN CANCER BIOLOGY
Volume 11, Issue 6, Pages 445-453Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/scbi.2001.0411
Keywords
IRF-7; LMP-1; EBV; latency
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Funding
- NCI NIH HHS [CA 19014] Funding Source: Medline
- NIAID NIH HHS [AI 42372-01] Funding Source: Medline
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Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV EBV latent membrane protein I (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
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