Journal
AUTOIMMUNITY REVIEWS
Volume 11, Issue 8, Pages 563-567Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2011.10.013
Keywords
SLE; Rituximab; Treatment
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Rituximab (Rituxan, Mabthera) is a monoclonal therapeutic anti-CD20 antibody approved for use in lymphoma and rheumatoid arthritis but not for use in systemic lupus erythematosus (SLE). Nonetheless, over the past decade many reports based on case series and observational studies have suggested benefits in selected groups of SLE patients with this monoclonal. It is also clear that off-label use of rituximab in SLE is not uncommon in many countries in the world. However, two randomized controlled clinical trials of rituximab failed to demonstrate a benefit for this agent, raising important questions on how to assess the potential role of rituximab in SLE. In this article I will review the available data and provide some comments that may be of use for the practicing clinician. (C) 2011 Elsevier B.V. All rights reserved.
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