Journal
CLINICAL GENETICS
Volume 60, Issue 6, Pages 421-430Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1399-0004.2001.600604.x
Keywords
Angelman; apraxia of speech; autism; chromosome 15; dyslexia; imprinting; interstitial duplication; phonological awareness deficit
Categories
Funding
- NICHD NIH HHS [K24 HDO1361, R01HD31491] Funding Source: Medline
Ask authors/readers for more resources
About 1% of individuals with autism or types of pervasive developmental disorder have a duplication of the 15q11-q13 region. These abnormalities can be detected by routine G-banded chromosome study, showing an extra marker chromosome, or demonstrated by fluorescence in situ hybridization (FISH) analysis, revealing an interstitial duplication. We report here the molecular, cytogenetic, clinical and neuropsychiatric evaluations of a family in whom 3 of 4 siblings inherited an interstitial duplication of 15q11-q13. This duplication was inherited from their mother who also had a maternally derived duplication. Affected family members had apraxia of speech, phonological awareness deficits, developmental language disorder, dyslexia, as well as limb apraxia but did not have any dysmorphic clinical features. The observations in this family suggest that the phenotypic manifestations of proximal 15q duplications may also involve language-based learning disabilities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available