Journal
AUTOIMMUNITY REVIEWS
Volume 8, Issue 3, Pages 190-195Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2008.07.042
Keywords
Chromatin remodeling; FoxP3; IL-2; Systemic lupus erythematosus; Transcriptional regulation
Categories
Funding
- PHS [R01 AI 49954]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI049954] Funding Source: NIH RePORTER
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The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described. (c) 2008 Elsevier B.V. All rights reserved.
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