Journal
AUTOIMMUNITY REVIEWS
Volume 7, Issue 6, Pages 453-456Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2008.03.015
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Human intravenous immunoglobulins (IVIg) contain natural autoantibodies against the inhibitory lectin-receptors Siglec-8 and Siglec-9. These two members of the Siglec family are known to mediate both inhibitory and death signals. Here, we discuss recent findings regarding the cytotoxic effects of natural anti-Siglec autoantibodies on both neutrophils and eosinophils, and present the concept of a novel regulatory mechanism exhibiting anti-inflammatory properties. Consequently, IVIg may amplify this regulatory pathway by increasing the concentration of natural anti-Siglec autoantibodies in blood and tissues. (C) 2008 Elsevier B.V. All rights reserved.
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