Journal
NEUROREPORT
Volume 12, Issue 17, Pages 3839-3844Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200112040-00047
Keywords
amyloid-beta; antisense peptide; cdc2; cyclin; olomoucine; phosphorylation
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The amyloid-beta (A beta) peptide has been implicated in the pathology of Alzheimer's disease (AD). Using an antisense peptide approach a novel interaction between A beta and the human cdc2 kinase was identified. The A beta 1-42, 1-40 and 25-35 peptides were shown to be substrates for the cdc2 kinase and phosphorylated on the Serine 26 residue. Phosphorylated A beta (pSA beta) was found in extracts from NT-2 neurons and AD brain. In NT-2 neurons the levels of pSA beta were increased in the presence of exogenous A beta and this increase was prevented by a cdc2 protein kinase inhibitor, olomoucine, that also prevented A beta cytotoxicity. The results from this study suggest that A beta phosphorylation by cdc2 could play a role in the brain pathology of AD. NeuroReport 12:3839-3844 (C) 2001 Lippincott Williams & Wilkins.
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