Journal
SCIENCE
Volume 294, Issue 5549, Pages 2172-2175Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1063224
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- NEI NIH HHS [R37 EY006837-14, R37 EY006837, R37 EY006837-13] Funding Source: Medline
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Heteromultimeric cyclic nucleotide-gated (CNG) channels play a central role in the transduction of odorant signals and subsequent adaptation. The contributions of individual subunits to native channel function in olfactory receptor neurons remain unclear. Here, we show that the targeted deletion of the mouse CNGA4 gene, which encodes a modulatory CNG subunit, results in a defect in odorant-dependent adaptation. Channels in excised membrane patches from the CNGA4 null mouse exhibited slower Ca2+-calmodulin-mediated channel desensitization. Thus, the CNGA4 subunit accelerates the Ca2+-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system.
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