Journal
AUTOIMMUNITY
Volume 45, Issue 5, Pages 388-399Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916934.2012.665523
Keywords
B cell; experimental autoimmune encephalomyelitis; immune regulation; immunoglobulin; multiple sclerosis
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Funding
- National Multiple Sclerosis Society [RG 3299-A-2]
- NIH, NIAID [R01 AI069358]
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A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, B cells have also been shown to have protective functions in that they play an essential role in the spontaneous recovery from EAE. In this review, we summarize studies conducted in a number of species demonstrating the conditions under which B cells are pathogenic in EAE. We also discuss the phenotype and anti-inflammatory mechanisms of regulatory B cells.
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