Journal
AUTOIMMUNITY
Volume 44, Issue 1, Pages 23-32Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916931003782148
Keywords
dendritic cells; autoimmunity; interleukin-2; regulatory T cells; tolerance
Categories
Funding
- European Union [LSHG-CT-2004-512074, HEALTH-F4-2008-202156, HEALTH-F4-2008-201842]
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Italian Ministry of Education and Research (COFIN)
Ask authors/readers for more resources
The induction and maintenance of T-cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of central and peripheral mechanisms act in parallel to inactivated, eliminated or control autoreactive T cells. Both centrally and peripherally, a key requirement for self-tolerance is the presentation of self-antigens in a correct context. There is now evidence to suggest that dendritic cells (DCs) play a fundamental role in the development of central and peripheral tolerance. In this review, we summarize recent progress toward the definition of the multiple roles of DCs in these processes. We will also discuss the association between defects in the DC compartment and the development of autoimmune responses, with particular reference to DC deregulation in the context of type I diabetes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available