Journal
AUTOIMMUNITY
Volume 44, Issue 1, Pages 33-42Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916931003782155
Keywords
Tregs; CD4(+)CD25(+)FOXP3(+) T cells; natural Tregs; autoimmunity
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Funding
- National Institutes of Health [AR53239]
- Arthritis Foundation Southern California Chapter
- Arthritis National Research Foundation
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The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.
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