Journal
AUTOIMMUNITY
Volume 43, Issue 1, Pages 48-55Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916930903374717
Keywords
Inflammation; autoimmunity; kinases
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Funding
- Rigel Pharmaceuticals, South San Francisco, CA, USA
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Spleen tyrosine kinase (Syk) is involved in the development and function of B and T cells, the Fc receptor-mediated degranulation of basophils and mast cells. Recent work has assigned important roles for Syk in the aberrant function of T cells in patients with systemic lupus erythematosus (SLE), osteoclasts, and urate crystal-induced neutrophil stimulation. Preclinical and early clinical studies have urged Syk inhibition for the treatment of patients with rheumatoid arthritis, whereas ex vivo experiments and preclinical studies point to a therapeutic potential of Syk inhibition in patients with SLE and crystal-induced arthritides.
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