Journal
AUTOIMMUNITY
Volume 42, Issue 7, Pages 596-604Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930903002495
Keywords
Giant cell arteritis; Takayasu arteritis; T cell; macrophages; cytokines; endothelial cell; vascular smooth muscle cell
Categories
Funding
- National Institutes of Health [RO1 AR42527, RO1 AR41974, R01 AI44142, U19 AI57266, RO1 EY11916, R01 AG15043, P30-EY06360]
- Research to Prevent Blindness Lew R. Wasserman Merit Award
- NATIONAL EYE INSTITUTE [P30EY006360, R01EY011916] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL117913, P01HL058000] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI057266, R01AI044142] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR041974, R01AR042527] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG015043] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Immune-mediated damage to medium-sized arteries results in wall remodeling with intimal hyperplasia, luminal stenosis and tissue ischemia. In the case of the aorta, vasculitis may result in dissection, aneurysm or rupture. The response-to-injury program of the blood vessel is a concerted action between the immune system and wall-resident cells, involving the release of growth and angiogenic factors from macrophages and giant cells and the migration and hyperproliferation of vascular smooth muscle cells. Innate immune cells, specifically, dendritic cells (DC) positioned in the vessel wall, have been implicated in the earliest steps of vasculitis. Pathogen-derived molecular patterns are capable of activating vascular DC and initiating adaptive immune responses. The pattern of the emerging vessel wall inflammation is ultimately determined by the initial insult. Ligands to toll-like receptor (TLR) 4, such as lipopolysaccharides, facilitate the recruitment of CD4 T cells that invade deep into the wall and distribute in a panarteritic pattern. Conversely, ligands for TLR5 condition vascular DC to support perivasculitic infiltrates. In essence, both innate and adaptive immune reactions collaborate to render the arterial wall susceptible to inflammatory damage. Unique features of the tissue microenvironment, including specialized DC, shape the course of the inflammatory response. Differences in vascular damage pattern encountered in different patients may relate to distinct instigators of vasculitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available