Journal
AUTOIMMUNITY
Volume 42, Issue 4, Pages 368-372Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930902832298
Keywords
NP; inflammation; in vivo imaging
Categories
Funding
- DFG
- ARC
- EPSRC through the award of the SIA in Nanometrology
- Engineering and Physical Sciences Research Council [EP/E032745/1, EP/E000584/1] Funding Source: researchfish
- EPSRC [EP/E032745/1, EP/E000584/1] Funding Source: UKRI
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The detection of subclinical early inflammation in autoimmune diseases is an important but currently technically demanding approach to direct initial diagnosis and subsequent choice of therapy. Recent advances in imaging using NP provides the potential to detect cellular recruitment, vascular activation or leakage at a subclinically stage of disease and may provide predictive biomarkers of future pathogenesis. The NP used are either untargeted and taken up by phagocytic cells, or are linked to a ligand, targeting localisation to the site of inflammation. Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation.
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