Journal
CELLULAR IMMUNOLOGY
Volume 214, Issue 2, Pages 99-109Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/cimm.2001.1894
Keywords
aging; quasi-monoclonal mouse; (4-hydroxy-3-nitrophenyl) acetyl; B cell; adoptive transfer; transgenic; immunopoiesis
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Funding
- NIA NIH HHS [IR15AG18791-01] Funding Source: Medline
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Increased dysfunction of the immune system with age can be attributed to developmental changes in cell types critical for proper immune responses. Previous studies have shown defects in humoral responses of aged individuals, but have not distinguished between aged T-cell/microenvironment and intrinsic B-cell defects. Here adoptive transfer of antigen-specific transgenic B cells compared early immunopoeisis from young and aged donors in a young recipient environment. B cells from aged donors demonstrated decreased antigen-induced expansion, particularly in the lymph nodes; however, they acquired a germinal center phenotype at frequencies similar to B cells from young donors. Additionally, aged B cells produced equivalent levels of antigen-specific antibody that underwent affinity maturation and isotype switching and demonstrated similar numbers of antibody-secreting cells of switched isotype. Thus, the ability of aged B cells to respond appropriately to T-dependent antigens and differentiate into high-affinity, isotype-switched, antibody-secreting cells appears to be intact. (C) 2001 Elsevier Science (USA).
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