Journal
NUCLEIC ACIDS RESEARCH
Volume 29, Issue 24, Pages 5195-5206Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/29.24.5195
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Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7),Salmonella typhi,Yersinia pestisandVibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.choleraethat is probably involved in the process of pathogenesis.
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