Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 194, Issue 12, Pages 1721-1730Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.12.1721
Keywords
CD4; T lymphocytes; helper; gene targeting; CD4-positive T lymphocytes
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Funding
- NIAID NIH HHS [R01 AI39506] Funding Source: Medline
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Absence of CD4 impairs the efficiency of T cell receptor (TCR) signaling in response to major histocompatibility complex (MHC) class II-presented peptides. Here we use mice carrying a conditional Cd4 allele to study the consequences of impaired TCR signaling after the completion of thymocyte development. We show that loss of CD4 decreases the steady-state proliferation of T cells as monitored by in vivo labeling with bromo-deoxyuridine. Moreover, T cells lacking CD4 compete poorly with CD4-expressitig T cells during proliferative expansion after transfer into lymphopenic recipients. The data suggest that T cells compete with one another during homeostatic proliferation, and indicate that the basis of this competition is TCR signaling.
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