Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 53, Issue 2, Pages 135-154Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(01)00225-3
Keywords
cancer gene therapy; gene expression; regulatory elements
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Funding
- NCI NIH HHS [R01 CA 74242, R01 CA 83821, N01 CO 97110] Funding Source: Medline
- NHLBI NIH HHS [R01 HL 50255] Funding Source: Medline
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Current treatment of solid tumors is limited by severe adverse effects, resulting in a narrow therapeutic index. Therefore, cancer gene therapy has emerged as a targeted approach that would significantly reduce undesired side effects in normal tissues. This approach requires a clear understanding of the molecular biology of both the malignant clone and the biological vectors that serve as vehicles to target cancer cells. In this review we discuss novel approaches for conditional gene expression in cancer cells. Targeting transgene expression to malignant tissues requires the use of specific regulatory elements including promoters based on tumor biology, tissue-specific promoters and inducible regulatory elements. We also discuss the regulation of both replication and transgene expression by conditionally-replicative viruses. These approaches have the potential to restrict the expression of transgenes exclusively to tissues of interest and thereby to increase the therapeutic index of future vectors for cancer gene therapy. (C) 2001 Elsevier Science B.V. All rights reserved.
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