Journal
AUTISM RESEARCH
Volume 2, Issue 3, Pages 157-177Publisher
WILEY
DOI: 10.1002/aur.80
Keywords
genetics; Asperger syndrome; autism; empathy; autistic traits; visual search; emotion recognition; SNP; broader autism phenotype
Categories
Funding
- Target Autism Genome (TAG)
- Nancy Lurie Marks (NLM) Family Foundation
- Elizabeth Rausing Family Trust
- Medical Research Council, UK
- ENSACP (N-EURO)
- MRC [MC_U105292688, G0600977] Funding Source: UKRI
- Medical Research Council [G0600977, MC_U105292688] Funding Source: researchfish
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Genetic studies of autism spectrum conditions (ASC) have mostly focused on the low functioning severe clinical subgroup, treating it as a rare disorder. However, ASC is now thought to be relatively common (similar to 1%), and representing one end of a quasi-normal distribution of autistic traits in the general population. Here we report a study of common genetic variation in candidate genes associated with autistic traits and Asperger syndrome (AS). We tested single nucleotide polymorphisms in 68 candidate genes in three functional groups (sex steroid synthesis/transport, neural connectivity, and social-emotional responsivity) in two experiments. These were (a) an association study of relevant behavioral traits (the Empathy Quotient (EQ), the Autism Spectrum Quotient (AQ) in a population sample (n = 349); and (b) a case-control association study on a sample of people with AS, a high-functioning subgroup of ASC (n = 174). 27 genes showed a nominally significant association with autistic traits and/or ASC diagnosis. Of these, 19 genes showed nominally significant association with AQ/EQ. In the sex steroid group, this included ESR2 and CYP11B1. In the neural connectivity group, this included HOXA1, NTRK1, and NLGN4X. In the socio-responsivity behavior group, this included MAOB, AVPR1B, and WFS1. Fourteen genes showed nominally significant association with AS. In the sex steroid group, this included CYP17A1 and CYP19A1. In the socio-emotional behavior group, this included OXT. Six genes were nominally associated in both experiments, providing a partial replication. Eleven genes survived family wise error rate (FWER) correction using permutations across both experiments, which is greater than would be expected by chance. CYP11B1 and NTRK1 emerged as significantly associated genes in both experiments, after EWER correction (P<0.05). This is the first candidate-gene association study of AS and of autistic traits. The most promising candidate genes require independent replication and fine mapping.
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