Journal
NEUROREPORT
Volume 12, Issue 18, Pages 4139-4142Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200112210-00055
Keywords
adrenomedullin; blood-brain barrier; cerebral endothelial cells; efflux pumps; permeability
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Adrenomedullin (AM) is an important vasodilator in cerebral circulation, and cerebral endothelial cells are a major source of AM. This in vitro study aimed to determine the AM-induced changes in blood-brain barrier (BBB) functions. All administration increased, whereas AM antisense oligonucleotide treatment decreased transendothelial electrical resistance. AM incubation decreased BBB permeability for sodium fluorescein (mol. wt 376 Da) but not for Evan's blue albumin (mol. wt 67 kDa), and it also attenuated fluid-phase endocytosis. AM treatment resulted in functional activation of P-glycoprotein efflux pump in vitro. Our results indicate that AM as an autocrine mediator plays an important role in the regulation of BBB properties of the cerebral endothelial cells. NeuroReport 12:4139-4142. (C) 2001 Lippincott Williams & Wilkins.
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