Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 66, Issue 26, Pages 8717-8721Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo010335e
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A new alkaloid, nomofungin, has been isolated from the fermentation broth of an unidentified endophytic fungus obtained from the bark of Ficus microcarpa L. The structure of nomofungin was determined by application of spectroscopic methods. The absolute stereochemistry of nomofungin was assigned by using the exciton chirality method. Nomofungin disrupts microfilaments in cultured mammalian cells and is moderately cytotoxic with minimum inhibitory concentrations (MICs) of 2 and 4.5 mug/mL against LoVo and KB cells, respectively. The ring system of nomofungin is unprecedented.
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