Journal
CELL
Volume 107, Issue 7, Pages 827-830Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(01)00623-7
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Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
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