Journal
TETRAHEDRON
Volume 58, Issue 2, Pages 261-264Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(01)01156-5
Keywords
trifluoromethyl enamines; stereoselection; lithium amide; Michael addition
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Chiral (alphaS)-(Z)-trifluoromethyl-beta-aryl-enamines were regio and stereoselectiveally prepared in excellent yields by the one pot reaction of 2-aryl-1-chloro-1-trifluoromethylethlene with lithium (alphaS)-(alpha-methylbenzyl) benzylamide. A mechanism involving elimination and addition processes is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.
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