Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 195, Issue 1, Pages 1-13Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20011432
Keywords
immunity; APCs; cellular; antibody formation; gram-positive bacteria
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Funding
- NIAID NIH HHS [1R01 AI49192, R01 AI046551, R01 AI049192] Funding Source: Medline
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Immature bone marrow-derived myeloid dendritic cells (BMDCs) are induced to undergo phenotypic maturation and secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12, and IL-10 when pulsed in vitro with intact Streptococcus pneumoniae. After transfer to naive mice, pulsed BMDCs induce immunoglobulin (Ig) isotype responses specific for both protein and polysaccharide pneumococcal antigens, having in common the requirement for viable BMDCS, T cells, and B7-dependent costimulation in the recipient mice. Whereas primary Ig isotype responses to bacterial proteins uniformly require BMDC expression of major histocompatibility complex class II, CD40, and 137, and the secretion of IL-6, but not IL-12, similar requirements for antipolysaccharide Ig responses were only observed for the IgG1 isotype.
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