Journal
SCIENCE
Volume 295, Issue 5553, Pages 319-320Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1067582
Keywords
-
Categories
Funding
- NEI NIH HHS [EY02430, EY13163] Funding Source: Medline
- NIGMS NIH HHS [GM37751] Funding Source: Medline
Ask authors/readers for more resources
Connexin genes encode intercellular channels that help to coordinate development. In mice, the targeted deletion of different connexins produces disparate effects on ocular growth and differentiation in the tens, and the need for multiple channel subunits is poorly understood. Knockout of Cx46 causes a loss of homeostasis and cataracts. Deletion of Cx50 results in reduced ocular growth and cataracts. Targeted replacement of Cx50 with Cx46 by genetic knock-in corrected defects in cellular differentiation and prevented cataracts, but did not restore normal growth. These data show that intrinsic properties of Cx50 were required for cellular growth, whereas nonspecific restoration of communication by Cx46 maintained differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available