Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 32, Issue 2, Pages 148-152Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(01)00782-1
Keywords
congestive heart failure; aging; lipophilic antioxidants; vitamin A; vitamin E; carotenoids; free radicals; oxidative stress
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Plasma levels of malondialdehyde (NIDA), vitamin A, and of antioxidant micronutrients including vitamin E, lutein, zeaxanthin, beta-cryptoxanthin, lycopene, and alpha- and beta-carotene were measured in 30 patients with class II and III congestive heart failure (CHF) according to the New, York Heart Association (NYHA) classification and in 55 controls. Ejection fraction was evaluated by echocardiography in all patients as a measure of the emptying capacity of the heart. Plasma levels of all measured compounds were significantly lower and MDA significantly higher in patients compared to controls (p<.001). Class II NYHA patients showed significantly lower MDA levels and significantly higher levels of vitamin A, vitamin E, lutein, and lycopene than class III patients. Ejection fraction was inversely correlated with MDA levels and directly correlated with vitamin A, vitamin E, lutein, and lycopene levels in patients. The present study supports the concept that an increased consumption of vitamin-rich fruits and vegetables might help in achieving cardiovascular health. (C) 2002 Elsevier Science Inc.
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